Influence of Reported Study Design Characteristics on Intervention Effect Estimates From Randomized, Controlled Trials

Savović, Jelena; E. Jones, Hayley; G. Altman, Douglas; Harris, Ross; Jüni, Peter; Pildal, Julie; Als‐Nielsen, Bodil; M. Balk, Ethan; Gluud, Christian; Lotte Gluud, Lise; P. A. Ioannidis, John; F. Schulz, Kenneth; Beynon, Rebecca; J. Welton, Nicky; Wood, Lesley; Moher, David; J Deeks, Jonathan; A C Sterne, Jonathan

doi:10.7326/0003-4819-157-6-201209180-00537

Public

Influence of Reported Study Design Characteristics on Intervention Effect Estimates From Randomized, Controlled Trials

Published in Annals of Internal Medicine • Sep 18, 2012

Authors:

Jelena Savović

Hayley E. Jones

Douglas G. Altman

Abstract

Published evidence suggests that aspects of trial design lead to biased intervention effect estimates, but findings from different studies are inconsistent. This study combined data from 7 meta-epidemiologic studies and removed overlaps to derive a final data set of 234 unique meta-analyses containi...

Subject

Medicine

Blinding

Odds ratio

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