Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

Feng, Saran; Cen, Jiannong; Huang, Yihong; Shen, Hongjie; Li, Yao; Wang, Yuanyuan; Chen, Zixing

doi:10.1371/journal.pone.0020599

Public

Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

Published in PLoS ONE • Aug 17, 2011

Authors:

Saran Feng

Jiannong Cen

Yihong Huang

Abstract

Central nervous system (CNS) involvement remains an important cause of morbidity and mortality in acute leukemia, the mechanisms of leukemic cell infiltration into the CNS have not yet been elucidated. The blood-brain barrier (BBB) makes CNS become a refugee to leukemic cells and serves as a resourc...

Subject

Occludin

Tight junction

Blood–brain barrier

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!