Influence of CYP3A5 and MDR1 (ABCB1) Polymorphisms on the Pharmacokinetics of Tacrolimus in Renal Transplant Recipients

Tsuchiya, Norihiko; Satoh, Shigeru; Tada, Hitoshi; Li, Zhenhua; Οhyama, Chikara; Sato, Kazunari; Suzuki, Toshio; Habuchi, Tomonori; Kato, Tetsuro

doi:10.1097/01.tp.0000137789.58694.b4

Public

Influence of CYP3A5 and MDR1 (ABCB1) Polymorphisms on the Pharmacokinetics of Tacrolimus in Renal Transplant Recipients

Published in Transplantation • Oct 19, 2004

Authors:

Norihiko Tsuchiya

Shigeru Satoh

Hitoshi Tada

Abstract

BACKGROUND: A body-weight-based dose of tacrolimus often results in marked individual diversity of blood drug concentration. Tacrolimus is a substrate for cytochrome P450 (CYP) 3A5 and p-glycoprotein encoded by CYP3A5 and MDR1 (ABCB1), respectively, having multiple single nucleotide polymorphisms. I...

Subject

Tacrolimus

Pharmacokinetics

CYP3A5

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