Expression level and differential JAK2-V617F–binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms

Baran‐Marszak, Fanny; Magdoud, Hajer; Desterke, Christophe; Alvarado‐Navarro, Anabell; Roger, Claudine; Harel, Stéphanie; Mazoyer, Elizabeth; Cassinat, Bruno; Chevret, Sylvie; Tonetti, Carole; Giraudier, Stéphane; Fenaux, Pierre; Cymbalista, Florence; Varin‐Blank, Nadine; Le Bousse‐Kerdilès, Marie‐Caroline; Kiladjian, Jean‐Jacques; Evelia Torres Velázquez, Laura

doi:10.1182/blood-2009-12-256768

Public

Expression level and differential JAK2-V617F–binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms

Published in Blood • Sep 25, 2010

Authors:

Fanny Baran‐Marszak

Hajer Magdoud

Christophe Desterke

Abstract

Activating mutations in signaling molecules, such as JAK2-V617F, have been associated with myeloproliferative neoplasms (MPNs). Mice lacking the inhibitory adaptor protein Lnk display deregulation of thrombopoietin/thrombopoietin receptor signaling pathways and exhibit similar myeloproliferative cha...

Subject

Thrombopoietin

Signal transducing adaptor protein

Thrombopoietin receptor

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