Innate and adaptive immune activation in the brain of MPS IIIB mouse model

DiRosario, Julianne; Divers, Erin; Wang, Chuansong; P. Etter, Jonathan; Charrier, Alyssa; Jukkola, Peter; Auer, Herbert; Best, Victoria; L. Newsom, David; M. McCarty, Douglas; Fu, Haiyan

doi:10.1002/jnr.21912

Public

Innate and adaptive immune activation in the brain of MPS IIIB mouse model

Published in Journal of Neuroscience Research • Oct 24, 2008

Authors:

Julianne DiRosario

Erin Divers

Chuansong Wang

Abstract

Mucopolysaccharidosis (MPS) IIIB is a lysosomal storage disease with severe neurological manifestations due to alpha-N-acetylglucosaminidase (NaGlu) deficiency. The mechanism of neuropathology in MPS IIIB is unclear. This study investigates the role of immune responses in neurological disease of MPS...

Subject

Immune system

Immunology

Acquired immune system

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