The accessible chromatin landscape of the human genome.

E Thurman, Robert; Rynes, Eric; Humbert, Richard; Vierstra, Jeff; T Maurano, Matthew; Haugen, Eric; C Sheffield, Nathan; B Stergachis, Andrew; Wang, Hao; Vernot, Benjamin; Garg, Kavita; John, Sam; Sandstrom, Richard; Bates, Daniel; Boatman, Lisa; K Canfield, Theresa; Diegel, Morgan; Dunn, Douglas; K Ebersol, Abigail; Frum, Tristan; Giste, Erika; K Johnson, Audra; M Johnson, Ericka; Kutyavin, Tanya; Lajoie, Bryan; Lee, Bum-Kyu; Lee, Kristen; London, Darin; Lotakis, Dimitra; Neph, Shane; Neri, Fidencio; D Nguyen, Eric; Qu, Hongzhu; P Reynolds, Alex; Roach, Vaughn; Safi, Alexias; E Sanchez, Minerva; Sanyal, Amartya; Shafer, Anthony; M Simon, Jeremy; Song, Lingyun; Vong, Shinny; Weaver, Molly; Yan, Yongqi; Zhang, Zhancheng; Zhang, Zhuzhu; Lenhard, Boris; Tewari, Muneesh; O Dorschner, Michael; Scott Hansen, R

doi:10.1038/nature11232

Public

The accessible chromatin landscape of the human genome.

Shared by NobleBlocks on Sep 6, 2012 • 12:00 AM UTC

Authors:

Robert E Thurman

Eric Rynes

Richard Humbert

Abstract

DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers and locus control regions. Here we present the first extensive map of human DHSs identified through gen...

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