The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

Mannion, Niamh; M. Greenwood, Sam; S. Young, Robert; L. Cox, Sarah; Brindle, James; F. Read, David; Nellåker, Christoffer; Vesely, Cornelia; P. Ponting, Chris; McLaughlin, Paul; F. Jantsch, Michael; R. Dorin, Julia; R. Adams, Ian; Scadden, A.D.J.; Öhman, Marie; P. Keegan, Liam; A. O’Connell, Mary

doi:10.1016/j.celrep.2014.10.041

Public

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

Published in Cell Reports • Nov 1, 2014

Authors:

Niamh Mannion

Sam M. Greenwood

Robert S. Young

Abstract

The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration. Adar1 mutant mouse embryos show aberrant interfer...

Subject

Innate immune system

RNA

RNA editing

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