Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

C. Luk, Kelvin; Kehm, Victoria; C. Carroll, Jenna; Zhang, Bin; O’Brien, Patrick; Q. Trojanowski, John; M.‐Y. Lee, Virginia

doi:10.1126/science.1227157

Public

Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

Published in Science • Nov 15, 2012

Authors:

Kelvin C. Luk

Victoria Kehm

Jenna C. Carroll

Abstract

Synthetic Parkinson's Parkinson's disease (PD) and related α-synucleinopathies are defined by the accumulation of α-synuclein (α-Syn)–containing intraneuronal inclusions—Lewy bodies (LBs) and Lewy neurites (LNs)—in association with the loss of dopaminergic neurons in the substantia nigra pars compac...

Subject

Substantia nigra

Pars compacta

Neurodegeneration

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