Mechanisms Driving Macrophage Diversity and Specialization in Distinct Tumor Microenvironments and Parallelisms with Other Tissues

Van Overmeire, Eva; Laoui, Damya; Keirsse, Jiri; A. Van Ginderachter, Jo; Sarukhan, Adélaïda

doi:10.3389/fimmu.2014.00127

Public

Mechanisms Driving Macrophage Diversity and Specialization in Distinct Tumor Microenvironments and Parallelisms with Other Tissues

Published in Frontiers in Immunology • Mar 26, 2014

Authors:

Eva Van Overmeire

Damya Laoui

Jiri Keirsse

Abstract

Macrophages are extremely versatile cells that adopt a distinct phenotype in response to a changing microenvironment. Consequently, macrophages are involved in diverse functions, ranging from organogenesis and tissue homeostasis to recognition and destruction of invading pathogens. In cancer, tumor-...

Subject

Tumor microenvironment

Biology

Macrophage

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