Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells

de Beaucoudrey, Ludovic; Puel, Anne; Filipe‐Santos, Orchidée; Cobat, Aurélie; Ghandil, Pegah; Chrabieh, Maya; Feinberg, Jacqueline; von Bernuth, Horst; Samarina, Arina; Jannière, Lucile; Fieschi, Claire; Stephan, Jean‐Louis; Boileau, Cathérine; Lyonnet, Stanislas; Jondeau, Guillaume; Cormier‐Daire, Valérie; Le Merrer, Martine; Hoarau, C.; Lebranchu, Yvon; Lortholary, Olivier; Chandesris, Marie‐Olivia; Tron, François; Gambineri, Eleonora; Bianchi, Lucia; Rodríguez‐Gallego, Carlos; Eva Zitnik, Simona; Vasconcelos, Julia; Guedes, Margarida; Bonito Vítor, Artur; Maródi, László; Chapel, Helen; Reid, Brenda; M. Roifman, Chaim; Nadal, David; Reichenbach, Janine; Caragol, Isabel; Garty, Ben‐Zion; Doğu, Figen; Çamcıoğlu, Yıldız; Gülle, Sanyie; Sanal, Özden; Fischer, Alain; Abel, Laurent; Stockinger, Brigitta; Pïcard, Capucine; Casanova, Jean‐Laurent

doi:10.1084/jem.20080321

Public

Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells

Published in The Journal of Experimental Medicine • Jun 30, 2008

Authors:

Ludovic de Beaucoudrey

Anne Puel

Orchidée Filipe‐Santos

Abstract

The cytokines controlling the development of human interleukin (IL) 17--producing T helper cells in vitro have been difficult to identify. We addressed the question of the development of human IL-17--producing T helper cells in vivo by quantifying the production and secretion of IL-17 by fresh T cel...

Subject

Biology

Immunology

Mutation

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