Conclusive Evidence That the Major T-cell Antigens of theMycobacterium tuberculosis Complex ESAT-6 and CFP-10 Form a Tight, 1:1 Complex and Characterization of the Structural Properties of ESAT-6, CFP-10, and the ESAT-6·CFP-10 Complex

S. Renshaw, Philip; Panagiotidou, Parthena; O. Whelan, Adam; V. Gordon, Stephen; Glyn Hewinson, R.; A. Williamson, Richard; D. Carr, Mark

doi:10.1074/jbc.m201625200

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Conclusive Evidence That the Major T-cell Antigens of theMycobacterium tuberculosis Complex ESAT-6 and CFP-10 Form a Tight, 1:1 Complex and Characterization of the Structural Properties of ESAT-6, CFP-10, and the ESAT-6·CFP-10 Complex

Published in Journal of Biological Chemistry • Jun 1, 2002

Authors:

Philip S. Renshaw

Parthena Panagiotidou

Adam O. Whelan

Abstract

The proteins ESAT-6 and CFP-10 have been shown to be secreted by Mycobacterium tuberculosis and Mycobacterium bovis cells, to be potent T-cell antigens, and to have a clear but as yet undefined role in tuberculosis pathogenesis. We have successfully overexpressed both ESAT-6 and CFP-10 in Escherichi...

Subject

ESAT-6

Circular dichroism

Mycobacterium tuberculosis

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