Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: Collagen accumulation in the young and loss in the aged

Horn, M; K. Graham, Helen; A. Richards, Mark; D. Clarke, Jessica; J. Greensmith, David; J. Briston, Sarah; Hall, Mark; M. Dibb, Katharine; W. Trafford, Andrew

doi:10.1016/j.yjmcc.2012.03.011

Public

Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: Collagen accumulation in the young and loss in the aged

Published in Journal of Molecular and Cellular Cardiology • Mar 30, 2012

Authors:

M Horn

Helen K. Graham

Mark A. Richards

Abstract

The incidence of heart failure (HF) increases with age. This study sought to determine whether aging exacerbates structural and functional remodeling of the myocardium in HF. HF was induced in young (~18 months) and aged sheep (>8 years) by right ventricular tachypacing. In non-paced animals, aging ...

Subject

Internal medicine

Heart failure

Extracellular matrix

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!