Evading Immune Cell Uptake and Clearance Requires PEG Grafting at Densities Substantially Exceeding the Minimum for Brush Conformation

Yang, Qi; Jones, Stephen; L. Parker, Christina; C. Zamboni, William; E. Bear, James; K. Lai, Samuel

doi:10.1021/mp400703d

Public

Evading Immune Cell Uptake and Clearance Requires PEG Grafting at Densities Substantially Exceeding the Minimum for Brush Conformation

Published in Molecular Pharmaceutics • Feb 12, 2014

Authors:

Qi Yang

Stephen Jones

Christina L. Parker

Abstract

Coating nanoparticles with polyethylene glycol (PEG), which reduces particle uptake and clearance by immune cells, is routinely used to extend the circulation times of nanoparticle therapeutics. Nevertheless, due to technical hurdles in quantifying the extent of PEG grafting, as well as in generatin...

Subject

PEG ratio

Polyethylene glycol

Grafting

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