Thioflavin T as an Efficient Inducer and Selective Fluorescent Sensor for the Human Telomeric G-Quadruplex DNA

Mohanty, Jyotirmayee; Barooah, N.; Dhamodharan, V.; Harikrishna, S.; I. Pradeepkumar, P.; C. Bhasikuttan, Achikanath

doi:10.1021/ja309588h

Public

Thioflavin T as an Efficient Inducer and Selective Fluorescent Sensor for the Human Telomeric G-Quadruplex DNA

Published in Journal of the American Chemical Society • Dec 6, 2012

Authors:

Jyotirmayee Mohanty

N. Barooah

V. Dhamodharan

Abstract

The quest for a G-quadruplex specific fluorescent sensor among other DNA forms under physiological salt conditions has been addressed in this article. We demonstrate for the first time the application of a water-soluble fluorogenic dye, Thioflavin T (ThT), in a dual role of exclusively inducing quad...

Subject

Chemistry

G-quadruplex

Antiparallel (mathematics)

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