Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.

Shtutman, Michael; Baig, Mirza; Levina, Elina; Hurteau, Gregory; Lim, Chang-Uk; Broude, Eugenia; Nikiforov, Mikhail; T Harkins, Timothy; Steven Carmack, C; Ding, Ye; Wieland, Felix; Buttyan, Ralph; B Roninson, Igor

doi:10.1073/pnas.1103842108

Public

Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.

Published in Proceedings of the National Academy of Sciences of the United States of America • Jul 26, 2011

NobleIDark:/48914/w1/20260526/224C9621Record on NobleID

Authors:

Michael Shtutman

,

Mirza Baig

,

Elina Levina

Abstract

Anticancer drugs are effective against tumors that depend on the molecular target of the drug. Known targets of cytotoxic anticancer drugs are involved in cell proliferation; drugs acting on such targets are ineffective against nonproliferating tumor cells, survival of which leads to eventual therap...

Discussions