Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

Bressanelli, Stéphane; Tomei, Licia; Roussel, Alain; Incitti, Ilario; Letizia Vitale, Rosa; Mathieu, Magali; De Francesco, Raffaele; A. Rey, Félix

doi:10.1073/pnas.96.23.13034

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

Shared by NobleBlocks on Nov 9, 1999 • 12:00 AM UTC

Authors:

Stéphane Bressanelli

Licia Tomei

Alain Roussel

Abstract

We report the crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus, a major human pathogen, to 2.8-Å resolution. This enzyme is a key target for developing specific antiviral therapy. The structure of the catalytic domain contains 531 residues folded in the characteristic finge...

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