Notch1 upregulates LPS‐induced macrophage activation by increasing NF‐κB activity

M. Monsalve, Eva; Ruiz‐García, Almudena; Baladrón, Victoriano; José Ruiz‐Hidalgo, María; Sánchez‐Solana, Beatriz; Rivero-Hinojosa, Samuel; Javier Garcı́a-Ramı́rez, José; Rubio, Antonio; Laborda, Jorge; José M. Díaz-Guerrá, María

doi:10.1002/eji.200838722

Public

Notch1 upregulates LPS‐induced macrophage activation by increasing NF‐κB activity

Published in European Journal of Immunology • Aug 6, 2009

Authors:

Eva M. Monsalve

Almudena Ruiz‐García

Victoriano Baladrón

Abstract

Macrophages present different Notch receptors and ligands on their surface. Following macrophage activation by LPS or other TLR ligands, Notch1 expression is upregulated. We report here that Notch signaling increases both basal and LPS-induced NF-kappaB activation, favoring the expression of genes i...

Subject

Notch signaling pathway

Cell biology

Phosphorylation

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