The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

B. Willingham, Stephen; Volkmer, Jens-Peter; J. Gentles, Andrew; Sahoo, Debashis; Dalerba, Piero; S. Mitra, Siddhartha; Wang, Jian; Contreras-Trujillo, Humberto; Martin, R.K.; D. Cohen, Justin; Lovelace, Patricia; A. Scheeren, Ferenc; P. Chao, Mark; Weiskopf, Kipp; Tang, Chad; Kathrin Volkmer, Anne; Jairaj Naik, Tejaswitha; A. Storm, Theresa; Mosley, Adriane; Edris, Badreddin; Schmid, Seraina; K. Sun, Chris; Chua, Mei‐Sze; Murillo, Oihana; S. Rajendran, Pradeep; C. Cha, Adriel; Chin, Robert; Kim, Dongkyoon; Adorno, Maddalena; Raveh, Tal; Tseng, Diane; Jaiswal, Siddhartha; Øyvind Enger, Per; K. Steinberg, Gary; Li, Gordon; So, Samuel; Majeti, Ravindra; R. Harsh, Griffith; van de Rijn, Matt; N.H. Teng, Nelson; B. Sunwoo, John; A. Alizadeh, Ash; F. Clarke, Michael; L. Weissman, Irving

doi:10.1073/pnas.1121623109

Public

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Published in Proceedings of the National Academy of Sciences • Mar 26, 2012

Authors:

Stephen B. Willingham

Jens-Peter Volkmer

Andrew J. Gentles

Abstract

CD47, a "don't eat me" signal for phagocytic cells, is expressed on the surface of all human solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue revealed that CD47 is overexpressed on cancer cells. CD47 mRNA expression levels correlated with a decreased probabi...

Subject

CD47

Cancer research

Phagocytosis

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