Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors

Arase, Hisashi; S. Mocarski, Edward; E. Campbell, Ann; B. Hill, Ann; L. Lanier, Lewis

doi:10.1126/science.1070884

Public

Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors

Published in Science • May 17, 2002

Authors:

Hisashi Arase

Edward S. Mocarski

Ann E. Campbell

Abstract

Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. ...

Subject

Receptor

Major histocompatibility complex

Biology

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