An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)

Yun‐Ju Huang, Ruby; K. Wong, M.; Zea Tan, Tuan; Theng Kuay, Kuee; Hsien Chun Ng, Aloysius; Yee Chung, Vin; Chu, Y-S; Matsumura, Noriomi; Lai, H-C; Lee, Yi-Fen; Sim, W.J.; Chai, Chee‐Yin; Pietschmann, Elke; Mori, Seiichi; Low, Jeffrey; Choolani, Mahesh; Paul Thiery, Jean

doi:10.1038/cddis.2013.442

Public

An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)

Published in Cell Death and Disease • Nov 7, 2013

Authors:

Ruby Yun‐Ju Huang

M. K. Wong

Tuan Zea Tan

Abstract

The phenotypic transformation of well-differentiated epithelial carcinoma into a mesenchymal-like state provides cancer cells with the ability to disseminate locally and to metastasise. Different degrees of epithelial-mesenchymal transition (EMT) have been found to occur in carcinomas from breast, c...

Subject

Anoikis

Epithelial–mesenchymal transition

Mesenchymal stem cell

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!