Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

Watanabe, Mitsuhiro; M. Houten, Sander; Wang, Li; Moschetta, Antonio; J. Mangelsdorf, David; A. Heyman, Richard; D. Moore, David; Auwerx, Johan

doi:10.1172/jci21025

Public

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

Published in Journal of Clinical Investigation • May 15, 2004

Authors:

Mitsuhiro Watanabe

Sander M. Houten

Li Wang

Abstract

We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of molecular, cellular, and animal models. Cholic acid (CA) prevents hepatic TG accumulation, VLDL secretion, and elevated serum TG in mouse models of hypertriglyceridemia. At the molecular level, CA decreases...

Subject

Farnesoid X receptor

Small heterodimer partner

Liver X receptor

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