New Alkyl-Lipid Blockers of SK3 Channels Reduce Cancer Cell Migration and Occurrence of Metastasis

Girault, Alban; Haelters, J.-P.; Potier‐Cartereau, Marie; Chantôme, Aurélie; Pinault, M.; Marionneau‐Lambot, Séverine; Oullier, Thibauld; Simon, Gaëlle; Couthon‐Gourvès, Hélène; Jaffrès, Paul‐Alain; Corbel, B.; Bougnoux, Philippe; Joulin, V.; Vandier, Christophe

doi:10.2174/156800911798073069

Public

New Alkyl-Lipid Blockers of SK3 Channels Reduce Cancer Cell Migration and Occurrence of Metastasis

Published in Current Cancer Drug Targets • Nov 1, 2011

Authors:

Alban Girault

J.-P. Haelters

Marie Potier‐Cartereau

Abstract

Edelfosine is an inhibitor of SK3 channel mediated cell migration. However, this compound bears adverse in vivo side effects. Using cell SK3 dependent cell-migration assay, patch-clamp, (125)I-apamin binding, and in vivo experiments we tested the ability of 15 lipid derivatives with chemical structu...

Subject

Apamin

Chemistry

Channel blocker

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