Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain

Orita, Sumihisa; Ishikawa, Tetsuhiro; Miyagi, Masayuki; Ochiai, Nobuyasu; Inoue, Gen; Eguchi, Yawara; Kamoda, Hiroto; Arai, Gen; Toyone, Tomoaki; Aoki, Yasuchika; Kubo, Takekazu; Takahashi, Kazuhisa; Ohtori, Seiji

doi:10.1186/1471-2474-12-134

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Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain

Published in BMC Musculoskeletal Disorders • Jun 16, 2011

Authors:

Sumihisa Orita

Tetsuhiro Ishikawa

Masayuki Miyagi

Abstract

BACKGROUND: The exact mechanism of knee osteoarthritis (OA)-associated pain is unclear, whereas mixed evidence of inflammatory pain and neuropathic pain has been noted. We aimed to investigate pain-related sensory innervation in a monoiodoacetate (MIA)-induced model of OA. METHODS: Sixty of seventy ...

Subject

Medicine

Calcitonin gene-related peptide

Allodynia

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