Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

Aarts, Michelle; Liu, Yitao; Liu, Lidong; Besshoh, Shintaro; Arundine, Mark; W. Gurd, James; Wang, Yu-Tian; W. Salter, Michael; Tymianski, Michael

doi:10.1126/science.1072873

Public

Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

Published in Science • Oct 24, 2002

Authors:

Michelle Aarts

Yitao Liu

Lidong Liu

Abstract

N-methyl-D-aspartate receptors (NMDARs) mediate ischemic brain damage but also mediate essential neuronal excitation. To treat stroke without blocking NMDARs, we transduced neurons with peptides that disrupted the interaction of NMDARs with the postsynaptic density protein PSD-95. This procedure dis...

Subject

Excitotoxicity

NMDA receptor

Postsynaptic potential

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