Synthesis and Antibacterial Activity of a Novel Series of Potent DNA Gyrase Inhibitors. Pyrazole Derivatives

Tanitame, Akihiko; Oyamada, Yoshihiro; Ofuji, Keiko; Fujimoto, Mika; Iwai, Noritaka; Hiyama, Yoichi; Suzuki, Kenji; Ito, Hideaki; Terauchi, Hideo; Kawasaki, Motoji; Nagai, Kazuo; Wachi, Masaaki; Yamagishi, Jun‐ichi

doi:10.1021/jm030394f

Public

Synthesis and Antibacterial Activity of a Novel Series of Potent DNA Gyrase Inhibitors. Pyrazole Derivatives

Published in Journal of Medicinal Chemistry • Jun 5, 2004

Authors:

Akihiko Tanitame

Yoshihiro Oyamada

Keiko Ofuji

Abstract

We have previously found that a pyrazole derivative 1 possesses antibacterial activity and inhibitory activity against DNA gyrase and topoisomerase IV. Here, we synthesized new pyrazole derivatives and found that 5-[(E)-2-(5-chloroindol-3-yl)vinyl]pyrazole 16 possesses potent antibacterial activity ...

Subject

DNA gyrase

Pyrazole

Chemistry

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