microRNAs exhibit high frequency genomic alterations in human cancer

Zhang, Lin; Huang, Jia; Yang, Nuo; Greshock, Joel; Megraw, Molly; Giannakakis, Antonis; Liang, Shun; L. Naylor, Tara; Barchetti, Andrea; Renee Ward, Michelle; Yao, George; Medina, Angélica; O’Brien-Jenkins, Ann; Katsaros, Dionyssios; G. Hatzigeorgiou, Artemis; A. Gimotty, Phyllis; Weber, Barbara; Coukos, George

doi:10.1073/pnas.0508889103

Public

microRNAs exhibit high frequency genomic alterations in human cancer

Published in Proceedings of the National Academy of Sciences • Jun 5, 2006

Authors:

Lin Zhang

Jia Huang

Nuo Yang

Abstract

MicroRNAs (miRNAs) are endogenous noncoding RNAs, which negatively regulate gene expression. To determine genomewide miRNA DNA copy number abnormalities in cancer, 283 known human miRNA genes were analyzed by high-resolution array-based comparative genomic hybridization in 227 human ovarian cancer, ...

Subject

microRNA

Biology

Copy-number variation

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