Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Shimada, Takashi; Kakitani, Makoto; Yamazaki, Y.; Hasegawa, Hisashi; Takeuchi, Yasuhiro; Fujita, Toshiro; Fukumoto, Seiji; Tomizuka, Kazuma; Yamashita, Takeyoshi

doi:10.1172/jci19081

Public

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Published in Journal of Clinical Investigation • Feb 15, 2004

Authors:

Takashi Shimada

Makoto Kakitani

Y. Yamazaki

Abstract

Inorganic phosphate is essential for ECM mineralization and also as a constituent of important molecules in cellular metabolism. Investigations of several hypophosphatemic diseases indicated that a hormone-like molecule probably regulates serum phosphate concentration. FGF23 has recently been recogn...

Subject

Fibroblast growth factor 23

Reabsorption

Endocrinology

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