Hepatitis C Virus Glycoprotein Complex Localization in the Endoplasmic Reticulum Involves a Determinant for Retention and Not Retrieval

Duvet, Sandrine; Cocquerel, Laurence; Pillez, André; Cacan, René; Verbert, André; Moradpour, Darius; Wychowski, Czeslaw; Dubuisson, Jean

doi:10.1074/jbc.273.48.32088

Public

Hepatitis C Virus Glycoprotein Complex Localization in the Endoplasmic Reticulum Involves a Determinant for Retention and Not Retrieval

Published in Journal of Biological Chemistry • Nov 1, 1998

Authors:

Sandrine Duvet

Laurence Cocquerel

André Pillez

Abstract

The hepatitis C virus (HCV) genome encodes two envelope glycoproteins (E1 and E2). These glycoproteins interact to form a noncovalent heterodimeric complex which in the cell accumulates in endoplasmic reticulum (ER)-like structures. The transmembrane domain of E2, at least, is involved in HCV glycop...

Subject

Golgi apparatus

Endoplasmic reticulum

Glycoprotein

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