Lactobacillus amylovorus Inhibits the TLR4 Inflammatory Signaling Triggered by Enterotoxigenic Escherichia coli via Modulation of the Negative Regulators and Involvement of TLR2 in Intestinal Caco-2 Cells and Pig Explants

Finamore, Alberto; Roselli, Marianna; Imbinto, Ambra; Seeboth, Julie; P. Oswald, Isabelle; Mengheri, Elena

doi:10.1371/journal.pone.0094891

Public

Lactobacillus amylovorus Inhibits the TLR4 Inflammatory Signaling Triggered by Enterotoxigenic Escherichia coli via Modulation of the Negative Regulators and Involvement of TLR2 in Intestinal Caco-2 Cells and Pig Explants

Published in PLoS ONE • Apr 14, 2014

Authors:

Alberto Finamore

Marianna Roselli

Ambra Imbinto

Abstract

Inflammation derived from pathogen infection involves the activation of toll-like receptor (TLR) signaling. Despite the established immunomodulatory activities of probiotics, studies relating the ability of such bacteria to inhibit the TLR signaling pathways are limited or controversial. In a previo...

Subject

Biology

TLR2

Enterotoxigenic Escherichia coli

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