High frequency of point mutations clustered within the adenosine triphosphate–binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance

Branford, Susan; Rudzki, Zbigniew; Walsh, Sonya; Grigg, Andrew; Arthur, Chris; Taylor, Kerry; Herrmann, Richard; P. Lynch, Kevin; P. Hughes, Timothy

doi:10.1182/blood.v99.9.3472

Public

High frequency of point mutations clustered within the adenosine triphosphate–binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance

Shared by NobleBlocks on May 1, 2002 • 12:00 AM UTC

Authors:

Susan Branford

Zbigniew Rudzki

Sonya Walsh

Abstract

Abstract Point mutations were found in the adenosine triphosphate (ATP) binding region of BCR/ABL in 12 of 18 patients with chronic myeloid leukemia (CML) or Ph-positive acute lymphoblastic leukemia (Ph+ ALL) and imatinib resistance (defined as loss of established hematologic response), but they wer...

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