Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells

Selmani, Zohair; Naji, Abderrahim; Zidi, Inès; Favier, Benoı̂t; Gaiffe, Émilie; Obert, Laurent; Borg, Christophe; Saas, Philippe; Tiberghien, Pierre; Rouas‐Freiss, Nathalie; D. Carosella, Edgardo; Deschaseaux, Frédéric

doi:10.1634/stemcells.2007-0554

Public

Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells

Published in Stem Cells • Oct 11, 2007

Authors:

Zohair Selmani

Abderrahim Naji

Inès Zidi

Abstract

Adult bone marrow-derived mesenchymal stem cells (MSCs) are multipotent cells that are the subject of intense investigation in regenerative medicine. In addition, MSCs possess immunomodulatory properties with therapeutic potential to prevent graft-versus-host disease (GvHD) in allogeneic hematopoiet...

Subject

Biology

Mesenchymal stem cell

Cell biology

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