Kaposi's Sarcoma-Associated Herpesvirus-Induced Upregulation of the c-<i>kit</i>Proto-Oncogene, as Identified by Gene Expression Profiling, Is Essential for the Transformation of Endothelial Cells

V. Moses, Ashlee; A. Jarvis, Michael; Raggo, Camilo; C. Bell, Yolanda; Ruhl, Rebecca; G. Mattias Luukkonen, B.; Griffith, Diana; L. Wait, Cecily; Druker, Brian; C. Heinrich, Michael; A. Nelson, Jay; Früh, Klaus

doi:10.1128/jvi.76.16.8383-8399.2002

Public

Kaposi's Sarcoma-Associated Herpesvirus-Induced Upregulation of the c-kitProto-Oncogene, as Identified by Gene Expression Profiling, Is Essential for the Transformation of Endothelial Cells

Published in Journal of Virology • Jul 28, 2002

Authors:

Ashlee V. Moses

Michael A. Jarvis

Camilo Raggo

Abstract

Kaposi's sarcoma (KS), the most frequent malignancy afflicting AIDS patients, is characterized by spindle cell formation and vascularization. Infection with KS-associated herpesvirus (KSHV) is consistently observed in all forms of KS. Spindle cell formation can be replicated in vitro by infection of...

Subject

Biology

Gene expression profiling

Downregulation and upregulation

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