Phenotype associated with APP duplication in five families

Cabrejo, L.; Guyant‐Maréchal, Lucie; Laquérrière, A.; Vercelletto, Martine; De La Fournière, F.; Thomas-Antérion, C.; Verny, Christophe; Letournel, Franck; Pasquier, Florence; Vital, Anne; Checler, Frédéric; Frébourg, Thierry; Campion, Dominique; Hannequin, Didier

doi:10.1093/brain/awl237

Public

Phenotype associated with APP duplication in five families

Published in Brain • Sep 7, 2006

Authors:

L. Cabrejo

Lucie Guyant‐Maréchal

A. Laquérrière

Abstract

Different duplications of the APP locus have been identified in five families with autosomal dominant early onset Alzheimer's disease (ADEOAD) and Abeta-related cerebral amyloid angiopathy (CAA). This study describes the phenotype of this new entity. Clinical, neuropsychological, imagery and neuropa...

Subject

Cerebral amyloid angiopathy

Dementia

Alzheimer's disease

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