Conserved vertebrate
                    <i>mir-451</i>
                    provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

Yang, Jr-Shiuan; Maurin, Thomas; Robine, Nicolas; D. Rasmussen, Kasper; L. Jeffrey, Kate; Chandwani, Rohit; P. Papapetrou, Eirini; Sadelain, Michel; O'Carroll, Dónal; C. Lai, Eric

doi:10.1073/pnas.1006432107

Public

Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

Shared by NobleBlocks on Aug 10, 2010 • 12:00 AM UTC

Authors:

Jr-Shiuan Yang

Thomas Maurin

Nicolas Robine

Abstract

Canonical animal microRNAs (miRNAs) are generated by sequential cleavage of precursor substrates by the Drosha and Dicer RNase III enzymes. Several variant pathways exploit other RNA metabolic activities to generate functional miRNAs. However, all of these pathways culminate in Dicer cleavage, sugge...

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