Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner.

Chatterjee, Samit; Prakash Dwivedi, Ved; Singh, Yogesh; Siddiqui, Imran; Sharma, Pawan; Van Kaer, Luc; Chattopadhyay, Debprasad; Das, Gobardhan

doi:10.1371/journal.ppat.1002378

Public

Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner.

Shared by NobleBlocks on Nov 1, 2011 • 12:00 AM UTC

Authors:

Samit Chatterjee

Ved Prakash Dwivedi

Yogesh Singh

Abstract

Despite its relatively poor efficacy, Bacillus Calmette-Guérin (BCG) has been used as a tuberculosis (TB) vaccine since its development in 1921. BCG induces robust T helper 1 (Th1) immune responses but, for many individuals, this is not sufficient for host resistance against Mycobacterium tuberculos...

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