Dimeric Zanamivir Conjugates with Various Linking Groups Are Potent, Long-Lasting Inhibitors of Influenza Neuraminidase Including H5N1 Avian Influenza

J. F. Macdonald, Simon; Cameron, Rachel; A. Demaine, Derek; J. Fenton, Rob; Foster, Graham; Gower, David; Hamblin, J.; Hamilton, Stephanie; Hart, Graham; P. Hill, Alan; G. A. Inglis, Graham; Jin, Betty; T. Jones, Haydn; B. McConnell, Darryl; L. McKimm‐Breschkin, Jennifer; Mills, Gail; Hung Nguyen, Van; J. Owens, Ian; R. Parry, N.; E. Shanahan, Stephen; Smith, Donna; G. Watson, Keith; Wu, Wen‐Yang; P. Tucker, Simon

doi:10.1021/jm040891b

Public

Dimeric Zanamivir Conjugates with Various Linking Groups Are Potent, Long-Lasting Inhibitors of Influenza Neuraminidase Including H5N1 Avian Influenza

Published in Journal of Medicinal Chemistry • Mar 16, 2005

Authors:

Simon J. F. Macdonald

Rachel Cameron

Derek A. Demaine

Abstract

The synthesis, antiviral and pharmacokinetic properties of zanamivir (ZMV) dimers 8 and 13 are described. The compounds are highly potent neuraminidase (NA) inhibitors which, along with dimer 3, are being investigated as potential second generation inhaled therapies both for the treatment of influen...

Subject

Zanamivir

Neuraminidase

Chemistry

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