Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

D. Roberson, Erik; Scearce-Levie, Kimberly; J. Palop, Jorge; Yan, Fengrong; H. Cheng, Irene; Wu, Tiffany; Gerstein, Hilary; Yu, Gui-Qiu; Mucke, Lennart

doi:10.1126/science.1141736

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Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Shared by NobleBlocks on May 4, 2007 • 12:00 AM UTC

Authors:

Erik D. Roberson

Kimberly Scearce-Levie

Jorge J. Palop

Abstract

Many potential treatments for Alzheimer's disease target amyloid-β peptides (Aβ), which are widely presumed to cause the disease. The microtubule-associated protein tau is also involved in the disease, but it is unclear whether treatments aimed at tau could block Aβ-induced cognitive impairments. He...

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