Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca<sup>2+</sup> signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus

Muroya, Shinji; Funahashi, Hisayuki; Yamanaka, Akihiro; Kohno, Daisuke; Uramura, Kazuhide; Nambu, Tadahiro; Shibahara, Megumi; Kuramochi, Motoki; Takigawa, Morikuni; Yanagisawa, Masashi; Sakurai, Takeshi; Shioda, Seiji; Yada, Toshihiko

doi:10.1111/j.1460-9568.2004.03255.x

Public

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus

Published in European Journal of Neuroscience • Mar 1, 2004

Authors:

Shinji Muroya

Hisayuki Funahashi

Akihiro Yamanaka

Abstract

Orexin-A and -B (hypocretin-1 and -2) have been implicated in the stimulation of feeding. Here we show the effector neurons and signaling mechanisms for the orexigenic action of orexins in rats. Immunohistochemical methods showed that orexin axon terminals contact with neuropeptide Y (NPY)- and proo...

Subject

Internal medicine

Endocrinology

Orexigenic

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