Brief report: inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis.

Samson, Maxime; Audia, Sylvain; Janikashvili, Nona; Ciudad, Marion; Trad, Malika; Fraszczak, Jennifer; Ornetti, Paul; Maillefert, Jean-Francis; Miossec, Pierre; Bonnotte, Bernard

doi:10.1002/art.34477

Public

Brief report: inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis.

Shared by NobleBlocks on Aug 1, 2012 • 12:00 AM UTC

Authors:

Maxime Samson

Sylvain Audia

Nona Janikashvili

Abstract

OBJECTIVE: From an immunologic standpoint, the mechanisms by which treatment with tocilizumab (TCZ), a humanized anti-interleukin-6 (anti-IL-6) receptor antibody, results in improvement in rheumatoid arthritis (RA) patients are still not fully understood. In vitro studies and studies in mouse models...

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