PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways

Chang, L; Graham, Peter; Hao, Jingli; Ni, Jie; Bucci, Joseph; Cozzi, Paul; H. Kearsley, John; Li, Yong

doi:10.1038/cddis.2014.415

Public

PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways

Published in Cell Death and Disease • Oct 2, 2014

Authors:

L Chang

Peter Graham

Jingli Hao

Abstract

The PI3K/Akt/mTOR pathway has a central role in cancer metastasis and radiotherapy. To develop effective therapeutics to improve radiosensitivity, understanding the possible pathways of radioresistance involved and the effects of a combination of the PI3K/Akt/mTOR inhibitors with radiotherapy on pro...

Subject

Radioresistance

PI3K/AKT/mTOR pathway

Radiosensitivity

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