Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

Heil, Florian; Hemmi, Hiroaki; Hochrein, Hubertus; Ampenberger, Franziska; J. Kirschning, Carsten; Akira, Shizuo; B. Lipford, Grayson; Wagner, Hermann; Bauer, Stefan

doi:10.1126/science.1093620

Public

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

Published in Science • Feb 23, 2004

Authors:

Florian Heil

Hiroaki Hemmi

Hubertus Hochrein

Abstract

Double-stranded ribonucleic acid (dsRNA) serves as a danger signal associated with viral infection and leads to stimulation of innate immune cells. In contrast, the immunostimulatory potential of single-stranded RNA (ssRNA) is poorly understood and innate immune receptors for ssRNA are unknown. We r...

Subject

TLR7

Innate immune system

Biology

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!