Cytotoxicity of Human Endogenous Retrovirus K–Specific T Cells toward Autologous Ovarian Cancer Cells

Rycaj, Kiera; B. Plummer, Joshua; Yin, Bingnan; Li, Ming; Garza, Jeremy; Radvanyi, Laszlo; M. Ramondetta, Lois; Lin, Kevin; L. Johanning, Gary; G. Tang, Dean; Wang‐Johanning, Feng

doi:10.1158/1078-0432.ccr-14-0388

Public

Cytotoxicity of Human Endogenous Retrovirus K–Specific T Cells toward Autologous Ovarian Cancer Cells

Published in Clinical Cancer Research • Nov 4, 2014

Authors:

Kiera Rycaj

Joshua B. Plummer

Bingnan Yin

Abstract

PURPOSE: To determine whether HERV-K envelope (ENV) protein could function as a tumor-associated antigen and elicit specific T-cell responses against autologous ovarian cancer cells. EXPERIMENTAL DESIGN: The expression of HERV-K transcripts and ENV protein, the presence of serum antibodies against H...

Subject

Ovarian cancer

Cytotoxic T cell

Antigen

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