Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

Ordanini, Stefania; Varga, Norbert; Porkolab, Vanessa; Thépaut, Michel; Belvisi, Laura; Bertaglia, Andrea; Palmioli, Alessandro; Berzi, Angela; Trabattoni, Daria; Clerici, Mario; Fieschi, Franck; Bernardi, Anna

doi:10.1039/c4cc09709b

Public

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

Shared by NobleBlocks on Jan 1, 2015 • 12:00 AM UTC

Authors:

Stefania Ordanini

Norbert Varga

Vanessa Porkolab

Abstract

Rational design of DC-SIGN antagonists combines a selective glycomimetic ligand with trivalent dendrons spaced by a rigid core and allows to exploit multiple multivalency effects.

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