Activation of Dual Oxidases Duox1 and Duox2

Rigutto, Sabrina; Hoste, Candice; Grasberger, Helmut; Milenkovic, Milutin; Communi, David; E. Dumont, Jacques; Corvilain, Bernard; Miot, Françoise; De Deken, Xavier

doi:10.1074/jbc.m806893200

Public

Activation of Dual Oxidases Duox1 and Duox2

Published in Journal of Biological Chemistry • Jan 15, 2009

Authors:

Sabrina Rigutto

Candice Hoste

Helmut Grasberger

Abstract

Dual oxidases were initially identified as NADPH oxidases producing H(2)O(2) necessary for thyroid hormone biosynthesis. The crucial role of Duox2 has been demonstrated in patients suffering from partial iodide organification defect caused by bi-allelic mutations in the DUOX2 gene. However, the Duox...

Subject

Dual (grammatical number)

Chemistry

Biochemistry

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