Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

Mayle, Allison; Yang, Liubin; Rodriguez, Benjamin; Zhou, Ting; Chang, Edmund; V. Curry, Choladda; A. Challen, Grant; Li, Wei; Wheeler, David; I. Rebel, Vivienne; A. Goodell, Margaret

doi:10.1182/blood-2014-08-594648

Public

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

Shared by NobleBlocks on Jan 22, 2015 • 12:00 AM UTC

Authors:

Allison Mayle

Liubin Yang

Benjamin Rodriguez

Abstract

Key Points Dnmt3a ablation in HSCs predisposes mice to develop a spectrum of myeloid and lymphoid malignancies. Dnmt3a-KO-derived myeloid malignancies and T-cell acute lymphocytic leukemia/lymphoma show distinct methylation aberrations.

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