Synthesis of a Novel Hydrazone Derivative and Biophysical Studies of Its Interactions with Bovine Serum Albumin by Spectroscopic, Electrochemical, and Molecular Docking Methods

Tian, Fang-Fang; Jiang, Feng‐Lei; Han, Xiao‐Le; Chen, Xiang; Ge, Yushu; Li, Jia‐Han; Zhang, Yue; Li, Ran; Ding, Xinliang; Liu, Yi

doi:10.1021/jp105766n

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Synthesis of a Novel Hydrazone Derivative and Biophysical Studies of Its Interactions with Bovine Serum Albumin by Spectroscopic, Electrochemical, and Molecular Docking Methods

Published in The Journal of Physical Chemistry B • Nov 1, 2010

Authors:

Fang-Fang Tian

Feng‐Lei Jiang

Xiao‐Le Han

Abstract

Hydrazone derivatives possess potential antitumor activities based on modulation of the iron metabolism in cancer cell. A novel hydrazone, N'-(2,4-dimethoxybenzylidene)-2-hydroxybenzohydrazide (DBH), has been synthesized and characterized, which is an analogue of 311 possessing potent anticancer act...

Subject

Bovine serum albumin

Hydrazone

Docking (animal)

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