Sequence-specific recognition, photocrosslinking and cleavage of the DNA double helix by an oligo-(α]-thymidylate covalently linked to an azidoproflavine derivative

Le Doan, Trung; Perrouault, Loı̈c; Praseuth, Danièle; Habhoub, Nourcddine; Décout, Jean‐Luc; T. Thuong, Nguyen; Lhomme, J.; Héène, Claude

doi:10.1093/nar/15.19.7749

Public

Sequence-specific recognition, photocrosslinking and cleavage of the DNA double helix by an oligo-(α]-thymidylate covalently linked to an azidoproflavine derivative

Published in Nucleic Acids Research • Jan 1, 1987

Authors:

Trung Le Doan

Loı̈c Perrouault

Danièle Praseuth

Abstract

A 3-azidoproflavine derivative was covalently linked to the 5'-end of an octathymidylate synthesized with the [alpha]-anomers of the nucleoside. Two target nucleic acids were used for this substituted oligo-[alpha]-thymidylate: a 27-mer single-stranded DNA fragment containing an octadeoxyadenylate s...

Subject

Biology

DNA

Cleavage (geology)

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