Cardiomyocyte VEGFR‐1 activation by VEGF‐B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction

Zentilin, Lorena; Puligadda, Uday; Lionetti, Vincenzo; Zacchigna, Serena; Collesi, Chiara; Pattarini, Lucia; Ruozi, Giulia; Camporesi, Silvia; Sinagra, Gianfranco; Pepe, Martino; A. Recchia, Fabio; Giacca, Mauro

doi:10.1096/fj.09-143180

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Cardiomyocyte VEGFR‐1 activation by VEGF‐B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction

Shared by NobleBlocks on Dec 17, 2009 • 12:00 AM UTC

Authors:

Lorena Zentilin

Uday Puligadda

Vincenzo Lionetti

Abstract

Mounting evidence indicates that the function of members of the vascular endothelial growth factor (VEGF) family extends beyond blood vessel formation. Here, we show that the prolonged intramyocardial expression of VEGF‐A 165 and VEGF‐B 167 on adeno‐associated virus‐mediated gene delivery determined...

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