Opening of the Mitochondrial Permeability Transition Pore Induces Reactive Oxygen Species Production at the Level of the Respiratory Chain Complex I

Batandier, Cécile; Leverve, Xavier; Fontaine, Éric

doi:10.1074/jbc.m310329200

Public

Opening of the Mitochondrial Permeability Transition Pore Induces Reactive Oxygen Species Production at the Level of the Respiratory Chain Complex I

Published in Journal of Biological Chemistry • Apr 1, 2004

Authors:

Cécile Batandier

Xavier Leverve

Éric Fontaine

Abstract

We have investigated the consequences of permeability transition pore (PTP) opening on the rate of production of reactive oxygen species in isolated rat liver mitochondria. We found that PTP opening fully inhibited H(2)O(2) production when mitochondria were energized both with complex I or II substr...

Subject

Mitochondrial permeability transition pore

Mitochondrion

Chemistry

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