Glucose Deprivation Contributes to the Development of
                    <i>KRAS</i>
                    Pathway Mutations in Tumor Cells

Yun, Jihye; Rago, Carlo; Cheong, Ian; Pagliarini, Ray; Angenendt, Philipp; Rajagopalan, Harith; Schmidt, Kerstin; K. V. Willson, James; Markowitz, Sandy; Zhou, Shibin; A. Diaz, Luis; E. Velculescu, Victor; Lengauer, Christoph; W. Kinzler, Kenneth; Vogelstein, Bert; Papadopoulos, Nickolas

doi:10.1126/science.1174229

Public

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

Shared by NobleBlocks on Sep 18, 2009 • 12:00 AM UTC

Authors:

Jihye Yun

Carlo Rago

Ian Cheong

Abstract

Desperately Seeking Glucose Mutations in oncogenes and tumor suppressor genes allow cancer cells to outgrow their neighboring healthy cells. What microenvironmental conditions provide a selective growth advantage to these cells? Yun et al. (p. 1555 , published online 6 August) identify low glucose a...

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